Elevated Circulating Interleukin-27 in Patients with Coronary Artery Disease Is Associated with Dendritic Cells, Oxidized Low-Density Lipoprotein, and Severity of Coronary Artery Stenosis
Joint Authors
Jin, Wen
Zhao, Yiqiao
Yan, Wen
Cao, Longxing
Zhang, Weiwei
Wang, Ming
Zhang, Ting
Fu, Qiang
Li, Zhiliang
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Coronary artery disease (CAD) is an immune-mediated chronic inflammatory disease mainly caused by atherosclerosis.
The aims of this study were to investigate the role of interleukin-27 (IL-27) in patients with CAD and the severity of coronary artery lesions, which was evaluated by Gensini score and to investigate the biosynthesis of IL-27 and oxidized low-density lipoprotein (ox-LDL) in vitro using monocyte-derived dendritic cells (DCs).
To this aim, plasma levels of IL-27, ox-LDL, and Gensini score were analyzed in patients with CAD (n=136) and normal subjects (controls, n=29).
IL-27 concentration of the supernatant and the mRNA expression levels of p28 and ebi3, subunits of IL-27, from cultured immature DCs incubated with different concentrations of ox-LDL for 24 h were also analyzed.
We found that circulating IL-27 levels were significantly elevated in patients with CAD than in controls (P<0.01), and positively correlated to ox-LDL and Gensini score.
ox-LDL dose-dependently upregulated expression of both IL-27 protein and IL-27 (p28 and EBI3) mRNA in vitro, indicating that ox-LDL can stimulate DCs to produce IL-27.
These results demonstrate that IL-27 might regulate the network of immunity and inflammation in the pathogenesis of atherosclerosis.
American Psychological Association (APA)
Jin, Wen& Zhao, Yiqiao& Yan, Wen& Cao, Longxing& Zhang, Weiwei& Wang, Ming…[et al.]. 2012. Elevated Circulating Interleukin-27 in Patients with Coronary Artery Disease Is Associated with Dendritic Cells, Oxidized Low-Density Lipoprotein, and Severity of Coronary Artery Stenosis. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1001162
Modern Language Association (MLA)
Jin, Wen…[et al.]. Elevated Circulating Interleukin-27 in Patients with Coronary Artery Disease Is Associated with Dendritic Cells, Oxidized Low-Density Lipoprotein, and Severity of Coronary Artery Stenosis. Mediators of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1001162
American Medical Association (AMA)
Jin, Wen& Zhao, Yiqiao& Yan, Wen& Cao, Longxing& Zhang, Weiwei& Wang, Ming…[et al.]. Elevated Circulating Interleukin-27 in Patients with Coronary Artery Disease Is Associated with Dendritic Cells, Oxidized Low-Density Lipoprotein, and Severity of Coronary Artery Stenosis. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1001162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001162