Expressions of CXCL12CXCR4 in Oral Premalignant and Malignant Lesions
Joint Authors
Xia, Juan
Chen, Na
Hong, Yun
Chen, Xiaobing
Tao, Xiaoan
Cheng, Bin
Huang, Yulei
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The chemokine receptor CXCR4 and its ligand CXCL12 have been suggested to play important roles in the initiation or progression of cancers.
The goal of the present study was to investigate alterations of CXCL12/CXCR4 in oral premalignant lesions and oral squamous cell carcinoma (OSCC).
Methods.
In 13 normal oral epithelia, 24 dysplastic oral leukoplakia (OLK), and 40 OSCC specimens, expressions of CXCL12 and CXCR4 were evaluated by immunohistochemistry.
Results.
CXCR4 was expressed in 37.5% of OLK and 60% of OSCC.
CXCL12 was detected in 50% of OLK and 62.5% of OSCC.
In OLK, CXCR4 positive ratio showed no significant difference from normal epithelia, but the CXCL12 positive ratio was significantly higher.
Significant relationship between CXCL12 and CXCR4 was found both in OLK and OSCC.
Conclusion.
Our results indicated that CXCL12/CXCR4 axis may play roles from early steps of oral malignant transformation and contribute to the progress of oral carcinogenesis.
American Psychological Association (APA)
Xia, Juan& Chen, Na& Hong, Yun& Chen, Xiaobing& Tao, Xiaoan& Cheng, Bin…[et al.]. 2012. Expressions of CXCL12CXCR4 in Oral Premalignant and Malignant Lesions. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1001167
Modern Language Association (MLA)
Xia, Juan…[et al.]. Expressions of CXCL12CXCR4 in Oral Premalignant and Malignant Lesions. Mediators of Inflammation No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-1001167
American Medical Association (AMA)
Xia, Juan& Chen, Na& Hong, Yun& Chen, Xiaobing& Tao, Xiaoan& Cheng, Bin…[et al.]. Expressions of CXCL12CXCR4 in Oral Premalignant and Malignant Lesions. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1001167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001167