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Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game
Joint Authors
Través, Paqui G.
Luque, Alfonso
Hortelano, Sonsoles
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The interaction between tumor progression and innate immune system has been well established in the last years.
Indeed, several lines of clinical evidence indicate that immune cells such as tumor-associated macrophages (TAMs) interact with tumor cells, favoring growth, angiogenesis, and metastasis of a variety of cancers.
In most tumors, TAMs show properties of an alternative polarization phenotype (M2) characterized by the expression of a series of chemokines, cytokines, and proteases that promote immunosuppression, tumor proliferation, and spreading of the cancer cells.
Tumor suppressor genes have been traditionally linked to the regulation of cancer progression; however, a growing body of evidence indicates that these genes also play essential roles in the regulation of innate immunity pathways through molecular mechanisms that are still poorly understood.
In this paper, we provide an overview of the immunobiology of TAMs as well as what is known about tumor suppressors in the context of immune responses.
Recent advances regarding the role of the tumor suppressor ARF as a regulator of inflammation and macrophage polarization are also reviewed.
American Psychological Association (APA)
Través, Paqui G.& Luque, Alfonso& Hortelano, Sonsoles. 2012. Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1001176
Modern Language Association (MLA)
Través, Paqui G.…[et al.]. Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game. Mediators of Inflammation No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1001176
American Medical Association (AMA)
Través, Paqui G.& Luque, Alfonso& Hortelano, Sonsoles. Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1001176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001176