Clinical Significance and Expression of PAF and TNF-alpha in Seminal Plasma of Leukocytospermic Patients
Joint Authors
Liu, Chaodong
Liu, Hongjian
Wang, Xianzhong
Xinbo, Sun
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Discuss the changes and roles of PAF in the reproductive tract infection by observing the expression of platelet activating factor (PAF) and tumor necrosis factor α (TNF-α) in seminal plasma of patients with leukocytospermia.
Methods.
The seminal plasma was obtained from 22 cases of leukocytospermia and 15 cases of normal males; the peroxidase dyeing method was adopted for seminal plasma white blood count; the ELISA was adopted to test PAF and TNF-α concentration in seminal plasma.
Result.
PAF concentration (2.14±0.43 ng/mL) of leukocytospermia group was significantly lower than the normal group (6.21±1.38 ng/mL, P<0.01) while TNF-α (5.51±1.46 ng/mL) was significantly higher than that of normal group (3.48±1.08 ng/mL).
There was negative correlation between PAF and TNF-α , (r=−0.68, P<0.01); the same situation existed in PAF and WBC (r=−0.62, P<0.01); but TNF-α was positively correlated to WBC (r=0.77, P<0.01).
Conclusion.
(1) Low expression of PAF and high expression of TNF-α in leukocytospermia affect the sperm motility, which is one of the reasons that leads to infertility.
(2) Lower expression of PAF has its particularity during the reproductive tract infection.
American Psychological Association (APA)
Liu, Chaodong& Liu, Hongjian& Wang, Xianzhong& Xinbo, Sun. 2012. Clinical Significance and Expression of PAF and TNF-alpha in Seminal Plasma of Leukocytospermic Patients. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1001191
Modern Language Association (MLA)
Liu, Chaodong…[et al.]. Clinical Significance and Expression of PAF and TNF-alpha in Seminal Plasma of Leukocytospermic Patients. Mediators of Inflammation No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-1001191
American Medical Association (AMA)
Liu, Chaodong& Liu, Hongjian& Wang, Xianzhong& Xinbo, Sun. Clinical Significance and Expression of PAF and TNF-alpha in Seminal Plasma of Leukocytospermic Patients. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1001191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001191