Macrolide Therapy in Respiratory Viral Infections
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Macrolides have received considerable attention for their anti-inflammatory and immunomodulatory actions beyond the antibacterial effect.
These two properties may ensure some efficacy in a wide spectrum of respiratory viral infections.
We aimed to summarize the properties of macrolides and their efficacy in a range of respiratory viral infection.
Methods.
A search of electronic journal articles through PubMed was performed using combinations of the following keywords including macrolides and respiratory viral infection.
Results.
Both in vitro and in vivo studies have provided evidence of their efficacy in respiratory viral infections including rhinovirus (RV), respiratory syncytial virus (RSV), and influenza virus.
Much data showed that macrolides reduced viral titers of RV ICAM-1, which is the receptor for RV, and RV infection-induced cytokines including IL-1β, IL-6, IL-8, and TNF-α.
Macrolides also reduced the release of proinflammatory cytokines which were induced by RSV infection, viral titers, RNA of RSV replication, and the susceptibility to RSV infection partly through the reduced expression of activated RhoA which is an RSV receptor.
Similar effects of macrolides on the influenza virus infection and augmentation of the IL-12 by macrolides which is essential in reducing virus yield were revealed.
Conclusion.
This paper provides an overview on the properties of macrolides and their efficacy in various respiratory diseases.
American Psychological Association (APA)
Min, Jin-Young& Jang, Yong Ju. 2012. Macrolide Therapy in Respiratory Viral Infections. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1001195
Modern Language Association (MLA)
Min, Jin-Young& Jang, Yong Ju. Macrolide Therapy in Respiratory Viral Infections. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1001195
American Medical Association (AMA)
Min, Jin-Young& Jang, Yong Ju. Macrolide Therapy in Respiratory Viral Infections. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1001195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001195