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Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis
Joint Authors
Houng, Jer-Yiing
Wang, Shih-Wei
Lin, Tsun-Mei
Wang, Chiou-Huey
Liu, Hsiao-Han
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study.
Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) cholesterol, were closely correlated with HOMA (homoeostasis model assessment) index in patients with nondiabetic RA.
Expressions of TLR2 in peripheral blood monocytes, following stimulation with peptidoglycan which is known as a TLR2 agonist, were closely correlated with the HOMA index, TNF-α, and IL-6 concentrations.
Accordingly, TLR-2 receptor and its related inflammatory cytokines could be potential therapeutic targets in managing insulin resistance in RA patients.
American Psychological Association (APA)
Wang, Shih-Wei& Lin, Tsun-Mei& Wang, Chiou-Huey& Liu, Hsiao-Han& Houng, Jer-Yiing. 2012. Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1001198
Modern Language Association (MLA)
Wang, Shih-Wei…[et al.]. Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis. Mediators of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1001198
American Medical Association (AMA)
Wang, Shih-Wei& Lin, Tsun-Mei& Wang, Chiou-Huey& Liu, Hsiao-Han& Houng, Jer-Yiing. Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1001198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001198