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Optimizing Dendritic Cell-Based Immunotherapy: Tackling the Complexity of Different Arms of the Immune System
Joint Authors
Van Brussel, Ilse
Berneman, Zwi N.
Cools, Nathalie
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Earlier investigations have revealed a surprising complexity and variety in the range of interaction between cells of the innate and adaptive immune system.
Our understanding of the specialized roles of dendritic cell (DC) subsets in innate and adaptive immune responses has been significantly advanced over the years.
Because of their immunoregulatory capacities and because very small numbers of activated DC are highly efficient at generating immune responses against antigens, DCs have been vigorously used in clinical trials in order to elicit or amplify immune responses against cancer and chronic infectious diseases.
A better insight in DC immunobiology and function has stimulated many new ideas regarding the potential ways forward to improve DC therapy in a more fundamental way.
Here, we discuss the continuous search for optimal in vitro conditions in order to generate clinical-grade DC with a potent immunogenic potential.
For this, we explore the molecular and cellular mechanisms underlying adequate immune responses and focus on most favourable DC culture regimens and activation stimuli in humans.
We envisage that by combining each of the features outlined in the current paper into a unified strategy, DC-based vaccines may advance to a higher level of effectiveness.
American Psychological Association (APA)
Van Brussel, Ilse& Berneman, Zwi N.& Cools, Nathalie. 2012. Optimizing Dendritic Cell-Based Immunotherapy: Tackling the Complexity of Different Arms of the Immune System. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1001199
Modern Language Association (MLA)
Van Brussel, Ilse…[et al.]. Optimizing Dendritic Cell-Based Immunotherapy: Tackling the Complexity of Different Arms of the Immune System. Mediators of Inflammation No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-1001199
American Medical Association (AMA)
Van Brussel, Ilse& Berneman, Zwi N.& Cools, Nathalie. Optimizing Dendritic Cell-Based Immunotherapy: Tackling the Complexity of Different Arms of the Immune System. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1001199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001199