Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery
Joint Authors
Akasaka, Takashi
Sun, Yujing
Gui, Ting
Shimokado, Aiko
Muragaki, Yasuteru
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cardiovascular disease, a leading cause of mortality in developed countries, is mainly caused by atherosclerosis, a chronic inflammatory disease.
Macrophages, which differentiate from monocytes that are recruited from the blood, account for the majority of leukocytes in atherosclerotic plaques.
Apoptosis and the suppressed clearance of apoptotic macrophages (efferocytosis) are associated with vulnerable plaques that are prone to rupture, leading to thrombosis.
Based on the central functions of macrophages in atherogenesis, cytokines, chemokines, enzymes, or microRNAs related to or produced by macrophages have become important clinical prognostic or diagnostic biomarkers.
This paper discusses the impact of monocyte-derived macrophages in early atherogenesis and advanced disease.
The role and possible future development of macrophage inflammatory biomarkers are also described.
American Psychological Association (APA)
Gui, Ting& Shimokado, Aiko& Sun, Yujing& Akasaka, Takashi& Muragaki, Yasuteru. 2012. Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1001201
Modern Language Association (MLA)
Gui, Ting…[et al.]. Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery. Mediators of Inflammation No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-1001201
American Medical Association (AMA)
Gui, Ting& Shimokado, Aiko& Sun, Yujing& Akasaka, Takashi& Muragaki, Yasuteru. Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1001201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001201