A Picrorhiza kurroa Derivative, Picroliv, Attenuates the Development of Dextran-Sulfate-Sodium-Induced Colitis in Mice
Joint Authors
Zhang, De-Kui
Yu, Jian-Jie
Li, Yu-Min
Wei, Li-Na
Yu, Yi
Feng, Yan-Hu
Wang, Xiang
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Free radicals and proinflammatory cytokines have been shown to play a critical role in the pathogenesis of ulcerative colitis (UC).
Picroliv, a Picrorhiza kurroa derivative, has been demonstrated to have antioxidant and anti-inflammatory effect.
The purpose of the study was to investigate the effects of picroliv on experimental model of UC in mice.
Materials and Methods.
Picroliv was administrated orally by gavage to mice with colitis induced by dextran sulfate sodium (DSS).
Disease activity index (DAI), colon length, and histology score were observed.
Myeloperoxidase (MPO) activity, and SOD, MDA concentrations were measured by enzyme-linked immunosorbent assay (ELISA) while the expression of cytokine mRNAs was studied by real-time-quantitative polymerase chain reaction and also ELISA.
The expression of NF-κB p65 was observed by immunohistochemistry staining and western blotting.
Results.
A significant improvement was observed in DAI and histological score in mice treated with picroliv, and incerased MPO activity, MDA concentrations, and the expression of IL-1β, TNF-α, and NF-κB p65 in mice with DSS-induced colitis were significantly reduced while decreased SOD level increased following administration of picroliv.
Conclusion.
The administration of picroliv leads to an amelioration of DSS-induced colitis, suggesting administration of picroliv may provide a therapeutic approach for UC.
American Psychological Association (APA)
Zhang, De-Kui& Yu, Jian-Jie& Li, Yu-Min& Wei, Li-Na& Yu, Yi& Feng, Yan-Hu…[et al.]. 2012. A Picrorhiza kurroa Derivative, Picroliv, Attenuates the Development of Dextran-Sulfate-Sodium-Induced Colitis in Mice. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1001218
Modern Language Association (MLA)
Zhang, De-Kui…[et al.]. A Picrorhiza kurroa Derivative, Picroliv, Attenuates the Development of Dextran-Sulfate-Sodium-Induced Colitis in Mice. Mediators of Inflammation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1001218
American Medical Association (AMA)
Zhang, De-Kui& Yu, Jian-Jie& Li, Yu-Min& Wei, Li-Na& Yu, Yi& Feng, Yan-Hu…[et al.]. A Picrorhiza kurroa Derivative, Picroliv, Attenuates the Development of Dextran-Sulfate-Sodium-Induced Colitis in Mice. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1001218
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001218