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The TregTh17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome
Joint Authors
Ye, Jin
Liu, Hui
Zhang, Gehua
Li, Peng
Wang, Zhiyuan
Huang, Shaotong
Yang, Qintai
Li, Yuan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Obstructive sleep apnoea syndrome (OSAS) is a chronic inflammatory disease regulated by T lymphocytes.
Our purpose is to assess the pattern of Th17 cells and CD4+CD25+Foxp3+ regulatory T (Treg) cells in peripheral blood of patients with OSAS.
Fourty-four OSAS men and 20 healthy volunteers were enrolled.
Twenty-three patients were classified into mild to moderate group and 21 cases were classified into severe group according to the severity of OSAS.
We detected the frequencies of Th17 and Treg and related serum cytokines secretion and expressions of key transcription factors.
OSAS patients revealed significant increase in peripheral Th17 number, Th17-related cytokines (IL-17 and IL-6), and RORγt mRNA levels.
They also presented a significant decrease in Treg number, Treg-related cytokines (TGF-β1), and Foxp3 mRNA levels as compared with normal persons.
As a result, the Th17/Treg ratios were markedly more upregulated in OSAS patients than those in control group.
Furthermore, the Th17/Treg ratio was positively related to the severity of OSAS and serum levels of C-reactive protein.
The development of OSAS may be associated with peripheral Th17/Treg imbalance and characterized by a proinflammatory cytokine microenvironment.
These results opened an alternative explanation for the substantial activation of immune cells in OSAS and the development of related complications.
American Psychological Association (APA)
Ye, Jin& Liu, Hui& Zhang, Gehua& Li, Peng& Wang, Zhiyuan& Huang, Shaotong…[et al.]. 2012. The TregTh17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1001231
Modern Language Association (MLA)
Ye, Jin…[et al.]. The TregTh17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome. Mediators of Inflammation No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1001231
American Medical Association (AMA)
Ye, Jin& Liu, Hui& Zhang, Gehua& Li, Peng& Wang, Zhiyuan& Huang, Shaotong…[et al.]. The TregTh17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1001231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001231