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Reactive Oxygen Species and Inhibitors of Inflammatory Enzymes, NADPH Oxidase, and iNOS in Experimental Models of Parkinson’s Disease
Joint Authors
Choi, Dong-Kug
Koppula, Sushruta
Kumar, Hemant
Kim, In-Su
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Reactive oxygen species (ROSs) are emerging as important players in the etiology of neurodegenerative disorders including Parkinson’s disease (PD).
Out of several ROS-generating systems, the inflammatory enzymes nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and inducible nitric oxide synthase (iNOS) were believed to play major roles.
Mounting evidence suggests that activation of NADPH oxidase and the expression of iNOS are directly linked to the generation of highly reactive ROS which affects various cellular components and preferentially damage midbrain dopaminergic neurons in PD.
Therefore, appropriate management or inhibition of ROS generated by these enzymes may represent a therapeutic target to reduce neuronal degeneration seen in PD.
Here, we have summarized recently developed agents and patents claimed as inhibitors of NADPH oxidase and iNOS enzymes in experimental models of PD.
American Psychological Association (APA)
Koppula, Sushruta& Kumar, Hemant& Kim, In-Su& Choi, Dong-Kug. 2012. Reactive Oxygen Species and Inhibitors of Inflammatory Enzymes, NADPH Oxidase, and iNOS in Experimental Models of Parkinson’s Disease. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-1001235
Modern Language Association (MLA)
Koppula, Sushruta…[et al.]. Reactive Oxygen Species and Inhibitors of Inflammatory Enzymes, NADPH Oxidase, and iNOS in Experimental Models of Parkinson’s Disease. Mediators of Inflammation No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-1001235
American Medical Association (AMA)
Koppula, Sushruta& Kumar, Hemant& Kim, In-Su& Choi, Dong-Kug. Reactive Oxygen Species and Inhibitors of Inflammatory Enzymes, NADPH Oxidase, and iNOS in Experimental Models of Parkinson’s Disease. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-1001235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001235