Usefulness of the Vitreous Fluid Analysis in the Translational Research of Diabetic Retinopathy
Joint Authors
Simó, Rafael
Simó-Servat, Olga
Hernández, Cristina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetic retinopathy (DR) is the major cause of acquired blindness in working-age adults.
Current treatments for DR (laser photocoagulation, intravitreal corticosteroids, intravitreal antivascular endothelial growth factor (VEGF) agents, and vitreo-retinal surgery) are applicable only at advanced stages of the disease and are associated with significant adverse effects.
Therefore, new pharmacological treatments for the early stages of the disease are needed.
Vitreous fluid obtained from diabetic patients undergoing vitreoretinal surgery is currently used to explore the events that are taking place in the retina for clinical research.
However, several confounding factors such as vitreous haemorrhage and concentration of vitreous proteins should be considered in the analysis of the results.
In this paper we will focus on the vitreous fluid as a tool for exploring the mediators of DR and in particular the molecules related to inflammatory pathways.
In addition, their role in the pathogenesis of DR will be discussed.
The usefulness of new technologies such as flow cytometry and proteomics in identifying new candidates involved in the inflammatory process that occurs in DR will be overviewed.
Finally, a more personalized treatment based on vitreous fluid analysis aiming to reduce the burden associated with DR is suggested.
American Psychological Association (APA)
Simó-Servat, Olga& Hernández, Cristina& Simó, Rafael. 2012. Usefulness of the Vitreous Fluid Analysis in the Translational Research of Diabetic Retinopathy. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1001245
Modern Language Association (MLA)
Simó-Servat, Olga…[et al.]. Usefulness of the Vitreous Fluid Analysis in the Translational Research of Diabetic Retinopathy. Mediators of Inflammation No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1001245
American Medical Association (AMA)
Simó-Servat, Olga& Hernández, Cristina& Simó, Rafael. Usefulness of the Vitreous Fluid Analysis in the Translational Research of Diabetic Retinopathy. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1001245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001245