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Inflammation and the Peritoneal Membrane: Causes and Impact on Structure and Function during Peritoneal Dialysis
Joint Authors
Pecoits-Filho, Roberto
Baroni, Gilberto
Schuinski, Adriana
de Moraes, Thyago P.
Meyer, Fernando
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Peritoneal dialysis therapy has increased in popularity since the end of the 1970s.
This method provides a patient survival rate equivalent to hemodialysis and better preservation of residual renal function.
However, technique failure by peritonitis, and ultrafiltration failure, which is a multifactorial complication that can affect up to 40% of patients after 3 years of therapy.
Encapsulant peritoneal sclerosis is an extreme and potentially fatal manifestation.
Causes of inflammation in peritoneal dialysis range from traditional factors to those related to chronic kidney disease per se, as well as from the peritoneal dialysis treatment, including the peritoneal dialysis catheter, dialysis solution, and infectious peritonitis.
Peritoneal inflammation generated causes significant structural alterations including: thickening and cubic transformation of mesothelial cells, fibrin deposition, fibrous capsule formation, perivascular bleeding, and interstitial fibrosis.
Structural alterations of the peritoneal membrane described above result in clinical and functional changes.
One of these clinical manifestations is ultrafiltration failure and can occur in up to 30% of patients on PD after five years of treatment.
An understanding of the mechanisms involved in peritoneal inflammation is fundamental to improve patient survival and provide a better quality of life.
American Psychological Association (APA)
Baroni, Gilberto& Schuinski, Adriana& de Moraes, Thyago P.& Meyer, Fernando& Pecoits-Filho, Roberto. 2012. Inflammation and the Peritoneal Membrane: Causes and Impact on Structure and Function during Peritoneal Dialysis. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-1001250
Modern Language Association (MLA)
Baroni, Gilberto…[et al.]. Inflammation and the Peritoneal Membrane: Causes and Impact on Structure and Function during Peritoneal Dialysis. Mediators of Inflammation No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-1001250
American Medical Association (AMA)
Baroni, Gilberto& Schuinski, Adriana& de Moraes, Thyago P.& Meyer, Fernando& Pecoits-Filho, Roberto. Inflammation and the Peritoneal Membrane: Causes and Impact on Structure and Function during Peritoneal Dialysis. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-1001250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001250