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Innate Immune Cells in Liver Inflammation
Joint Authors
Liaskou, Evaggelia
Wilson, Daisy V.
Oo, Ye H.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-09
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Innate immune system is the first line of defence against invading pathogens that is critical for the overall survival of the host.
Human liver is characterised by a dual blood supply, with 80% of blood entering through the portal vein carrying nutrients and bacterial endotoxin from the gastrointestinal tract.
The liver is thus constantly exposed to antigenic loads.
Therefore, pathogenic microorganism must be efficiently eliminated whilst harmless antigens derived from the gastrointestinal tract need to be tolerized in the liver.
In order to achieve this, the liver innate immune system is equipped with multiple cellular components; monocytes, macrophages, granulocytes, natural killer cells, and dendritic cells which coordinate to exert tolerogenic environment at the same time detect, respond, and eliminate invading pathogens, infected or transformed self to mount immunity.
This paper will discuss the innate immune cells that take part in human liver inflammation, and their roles in both resolution of inflammation and tissue repair.
American Psychological Association (APA)
Liaskou, Evaggelia& Wilson, Daisy V.& Oo, Ye H.. 2012. Innate Immune Cells in Liver Inflammation. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-1001258
Modern Language Association (MLA)
Liaskou, Evaggelia…[et al.]. Innate Immune Cells in Liver Inflammation. Mediators of Inflammation No. 2012 (2012), pp.1-21.
https://search.emarefa.net/detail/BIM-1001258
American Medical Association (AMA)
Liaskou, Evaggelia& Wilson, Daisy V.& Oo, Ye H.. Innate Immune Cells in Liver Inflammation. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-1001258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001258