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Peripheral Mechanisms of Dental Pain: The Role of Substance P
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Current evidence supports the central role of neuropeptides in the molecular mechanisms underlying dental pain.
In particular, substance P, a neuropeptide produced in neuron cell bodies localised in dorsal root and trigeminal ganglia, contributes to the transmission and maintenance of noxious stimuli and inflammatory processes.
The major role of substance P in the onset of dental pain and inflammation is increasingly being recognised.
Well-grounded experimental and clinical observations have documented an increase in substance P concentration in patients affected by caries, pulpitis, or granulomas and in those undergoing standard orthodontic or orthodontic/dental care procedures.
This paper focuses on the role of substance P in the induction and maintenance of inflammation and dental pain, in order to define future lines of research for the evaluation of therapeutic strategies aimed at modulating the complex effects of this mediator in oral tissues.
American Psychological Association (APA)
Sacerdote, Paola& Levrini, L.. 2012. Peripheral Mechanisms of Dental Pain: The Role of Substance P. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1001261
Modern Language Association (MLA)
Sacerdote, Paola& Levrini, L.. Peripheral Mechanisms of Dental Pain: The Role of Substance P. Mediators of Inflammation No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1001261
American Medical Association (AMA)
Sacerdote, Paola& Levrini, L.. Peripheral Mechanisms of Dental Pain: The Role of Substance P. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1001261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001261