The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages
Joint Authors
Oh, Jueun
Jeong, Deok
Yi, Young-Su
Yu, Tao
Yang, Yanyan
Cho, Jae Youl
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants.
Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease.
Recently, an increasing number of studies have focused on inflammatory diseases.
TBK1 is a serine/threonine-protein kinase which regulates antiviral defense, host-virus interaction, and immunity.
It is ubiquitously expressed in mouse stomach, colon, thymus, and liver.
Interestingly, high levels of active TBK1 have also been found to be associated with inflammatory diseases, indicating that TBK1 is closely related to inflammatory responses.
Even though relatively few studies have addressed the functional roles of TBK1 relating to inflammation, this paper discusses some recent findings that support the critical role of TBK1 in inflammatory diseases and underlie the necessity of trials to develop useful remedies or therapeutics that target TBK1 for the treatment of inflammatory diseases.
American Psychological Association (APA)
Yu, Tao& Yi, Young-Su& Yang, Yanyan& Oh, Jueun& Jeong, Deok& Cho, Jae Youl. 2012. The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1001266
Modern Language Association (MLA)
Yu, Tao…[et al.]. The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages. Mediators of Inflammation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1001266
American Medical Association (AMA)
Yu, Tao& Yi, Young-Su& Yang, Yanyan& Oh, Jueun& Jeong, Deok& Cho, Jae Youl. The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1001266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001266