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Calorie Restriction with a High-Fat Diet Effectively Attenuated Inflammatory Response and Oxidative Stress-Related Markers in Obese Tissues of the High Diet Fed Rats
Joint Authors
Lim, Yunsook
Park, Seungae
Park, Na-Young
Giuseppe, Valacchi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Obesity characterized by increased mass of adipose tissue leads to systemic inflammation.
Calorie restriction (CR) improves parameters associated with immune response and antioxidant defense.
We hypothesized that CR with a high fat diet (HFCR) regulates local and systemic inflammation and oxidative stress damage in a high fat diet induced obesity (HF group).
We investigated effect of HFCR on inflammation and oxidative stress-related markers in liver and adipose tissues as well as adipokines in plasma.
HFCR lowered liver triglyceride levels, total cholesterol levels, and the plasma leptin/adiponectin ratio to normal levels and improved glucose tolerance.
HFCR also improved fatty liver and normalized adipocyte size and morphology.
HFCR reduced lipid peroxidation and decreased the expression levels of inducible nitric oxide synthetase, cyclooxygenase-2, NF-E2-related factor, and heme oxygenase-1 in the liver.
Moreover, HFCR suppressed the expression levels of C- reactive protein and manganese superoxide dismutase in the adipose tissue in the HF group.
These results suggest that HFCR may have beneficial effects on inflammation and oxidative stress as well as lipid profiles in the HF diet induced obesity.
Moreover, HFCR may be a good way to increase compliance in obese patients and to prevent obesity induced complications without changes in dietary pattern.
American Psychological Association (APA)
Park, Seungae& Park, Na-Young& Giuseppe, Valacchi& Lim, Yunsook. 2012. Calorie Restriction with a High-Fat Diet Effectively Attenuated Inflammatory Response and Oxidative Stress-Related Markers in Obese Tissues of the High Diet Fed Rats. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1001267
Modern Language Association (MLA)
Park, Seungae…[et al.]. Calorie Restriction with a High-Fat Diet Effectively Attenuated Inflammatory Response and Oxidative Stress-Related Markers in Obese Tissues of the High Diet Fed Rats. Mediators of Inflammation No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1001267
American Medical Association (AMA)
Park, Seungae& Park, Na-Young& Giuseppe, Valacchi& Lim, Yunsook. Calorie Restriction with a High-Fat Diet Effectively Attenuated Inflammatory Response and Oxidative Stress-Related Markers in Obese Tissues of the High Diet Fed Rats. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1001267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1001267