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Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-12
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Down syndrome is a complex disease that has challenged molecular and cellular research for more than 50 years.
Understanding the molecular bases of morphological, cellular, and functional alterations resulting from the presence of an additional complete chromosome 21 would aid in targeting specific genes and pathways for rescuing some phenotypes.
Recently, progress has been made by characterization of brain alterations in mouse models of Down syndrome.
This review will highlight the main molecular and cellular findings recently described for these models, particularly with respect to their relationship to Down syndrome phenotypes.
American Psychological Association (APA)
Créau, Nicole. 2012. Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics. Neural Plasticity،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1002337
Modern Language Association (MLA)
Créau, Nicole. Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics. Neural Plasticity No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-1002337
American Medical Association (AMA)
Créau, Nicole. Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1002337
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002337