Identification and Characterization of Two Novel RNA Editing Sites in grin1b Transcripts of Embryonic Danio rerio
Joint Authors
Pozo, Pedro
Hoopengardner, Barry
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Discovering RNA editing sites in model organisms provides an insight into their adaptations in addition to finding potential sites for the regulation of neural activity and the basis of integrated models of metazoan editing with a variety of applications, including potential clinical treatments of neural dysregulation.
The zebrafish, Danio rerio, is an important vertebrate model system.
We focused on the grin1b gene of zebrafish due to its important function in the nervous tissue as a glutamate receptor.
Using a comparative sequence-based approach, we located possible RNA editing events within the grin1b transcript.
Surprisingly, sequence analysis also revealed a new editing site which was not predicted by the comparative approach.
We here report the discovery of two novel RNA editing events in grin1b transcripts of embryonic zebrafish.
The frequency of these editing events and their locations within the grin1b transcript are also described.
American Psychological Association (APA)
Pozo, Pedro& Hoopengardner, Barry. 2012. Identification and Characterization of Two Novel RNA Editing Sites in grin1b Transcripts of Embryonic Danio rerio. Neural Plasticity،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002340
Modern Language Association (MLA)
Pozo, Pedro& Hoopengardner, Barry. Identification and Characterization of Two Novel RNA Editing Sites in grin1b Transcripts of Embryonic Danio rerio. Neural Plasticity No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1002340
American Medical Association (AMA)
Pozo, Pedro& Hoopengardner, Barry. Identification and Characterization of Two Novel RNA Editing Sites in grin1b Transcripts of Embryonic Danio rerio. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002340