Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders
Joint Authors
Pozzo-Miller, Lucas
Hartmann, David
Drummond, Jana
Handberg, Erik
Ewell, Sharday
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Studies utilizing genetic and pharmacological manipulations in rodent models and neuronal cultures have revealed myriad roles of brain-derived neurotrophic factor (BDNF).
Currently, this knowledge of BDNF function is being translated into improvement strategies for several debilitating neurological disorders in which BDNF abnormalities play a prominent role.
Common among the BDNF-related disorders are irregular trafficking and release of mature BDNF (mBDNF) and/or its prodomain predecessor, proBDNF.
Thus, investigating the conditions required for proper trafficking and release of BDNF is an essential step toward understanding and potentially improving these neurological disorders.
This paper will provide examples of disorders related to BDNF release and serve as a review of the techniques being used to study the trafficking and release of BDNF.
American Psychological Association (APA)
Hartmann, David& Drummond, Jana& Handberg, Erik& Ewell, Sharday& Pozzo-Miller, Lucas. 2012. Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders. Neural Plasticity،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1002359
Modern Language Association (MLA)
Hartmann, David…[et al.]. Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders. Neural Plasticity No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1002359
American Medical Association (AMA)
Hartmann, David& Drummond, Jana& Handberg, Erik& Ewell, Sharday& Pozzo-Miller, Lucas. Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1002359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002359