Erasing Synapses in Sleep: Is It Time to Be SHY?
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Converging lines of evidence strongly support a role for sleep in brain plasticity.
An elegant idea that may explain how sleep accomplishes this role is the “synaptic homeostasis hypothesis (SHY).” According to SHY, sleep promotes net synaptic weakening which offsets net synaptic strengthening that occurs during wakefulness.
SHY is intuitively appealing because it relates the homeostatic regulation of sleep to an important function (synaptic plasticity).
SHY has also received important experimental support from recent studies in Drosophila melanogaster.
There remain, however, a number of unanswered questions about SHY.
What is the cellular mechanism governing SHY? How does it fit with what we know about plasticity mechanisms in the brain? In this review, I discuss the evidence and theory of SHY in the context of what is known about Hebbian and non-Hebbian synaptic plasticity.
I conclude that while SHY remains an elegant idea, the underlying mechanisms are mysterious and its functional significance unknown.
American Psychological Association (APA)
Frank, Marcos Gabriel. 2012. Erasing Synapses in Sleep: Is It Time to Be SHY?. Neural Plasticity،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1002370
Modern Language Association (MLA)
Frank, Marcos Gabriel. Erasing Synapses in Sleep: Is It Time to Be SHY?. Neural Plasticity No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-1002370
American Medical Association (AMA)
Frank, Marcos Gabriel. Erasing Synapses in Sleep: Is It Time to Be SHY?. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1002370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002370