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Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity
Joint Authors
Wang, Hui
Megill, Andrea
He, Kaiwen
Kirkwood, Alfredo
Lee, Hey-Kyoung
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-26
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Alzheimer's disease (AD) is a neurodegenerative disease, one of whose major pathological hallmarks is the accumulation of amyloid plaques comprised of aggregated β-amyloid (Aβ) peptides.
It is now recognized that soluble Aβ oligomers may lead to synaptic dysfunctions early in AD pathology preceding plaque deposition.
Aβ is produced by a sequential cleavage of amyloid precursor protein (APP) by the activity of β- and γ-secretases, which have been identified as major candidate therapeutic targets of AD.
This paper focuses on how Aβ alters synaptic function and the functional consequences of inhibiting the activity of the two secretases responsible for Aβ generation.
Abnormalities in synaptic function resulting from the absence or inhibition of the Aβ-producing enzymes suggest that Aβ itself may have normal physiological functions which are disrupted by abnormal accumulation of Aβ during AD pathology.
This interpretation suggests that AD therapeutics targeting the β- and γ-secretases should be developed to restore normal levels of Aβ or combined with measures to circumvent the associated synaptic dysfunction(s) in order to have minimal impact on normal synaptic function.
American Psychological Association (APA)
Wang, Hui& Megill, Andrea& He, Kaiwen& Kirkwood, Alfredo& Lee, Hey-Kyoung. 2012. Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity. Neural Plasticity،Vol. 2012, no. 2012, pp.1-24.
https://search.emarefa.net/detail/BIM-1002371
Modern Language Association (MLA)
Wang, Hui…[et al.]. Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity. Neural Plasticity No. 2012 (2012), pp.1-24.
https://search.emarefa.net/detail/BIM-1002371
American Medical Association (AMA)
Wang, Hui& Megill, Andrea& He, Kaiwen& Kirkwood, Alfredo& Lee, Hey-Kyoung. Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-24.
https://search.emarefa.net/detail/BIM-1002371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002371