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Pathological Plasticity in Fragile X Syndrome
Joint Authors
Martin, Brandon S.
Huntsman, Molly M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Deficits in neuronal plasticity are common hallmarks of many neurodevelopmental disorders.
In the case of fragile-X syndrome (FXS), disruption in the function of a single gene, FMR1, results in a variety of neurological consequences directly related to problems with the development, maintenance, and capacity of plastic neuronal networks.
In this paper, we discuss current research illustrating the mechanisms underlying plasticity deficits in FXS.
These processes include synaptic, cell intrinsic, and homeostatic mechanisms both dependent on and independent of abnormal metabotropic glutamate receptor transmission.
We place particular emphasis on how identified deficits may play a role in developmental critical periods to produce neuronal networks with permanently decreased capacity to dynamically respond to changes in activity central to learning, memory, and cognition in patients with FXS.
Characterizing early developmental deficits in plasticity is fundamental to develop therapies that not only treat symptoms but also minimize the developmental pathology of the disease.
American Psychological Association (APA)
Martin, Brandon S.& Huntsman, Molly M.. 2012. Pathological Plasticity in Fragile X Syndrome. Neural Plasticity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1002373
Modern Language Association (MLA)
Martin, Brandon S.& Huntsman, Molly M.. Pathological Plasticity in Fragile X Syndrome. Neural Plasticity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1002373
American Medical Association (AMA)
Martin, Brandon S.& Huntsman, Molly M.. Pathological Plasticity in Fragile X Syndrome. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1002373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002373