Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats
Joint Authors
González-Burgos, Ignacio
Rivera-Cervantes, Martha C.
Velázquez-Zamora, Dulce A.
Feria-Velasco, Alfredo
Garcia-Segura, Luis Miguel
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Some selective estrogen receptor modulators, such as raloxifene and tamoxifen, are neuroprotective and reduce brain inflammation in several experimental models of neurodegeneration.
In addition, raloxifene and tamoxifen counteract cognitive deficits caused by gonadal hormone deprivation in male rats.
In this study, we have explored whether raloxifene and tamoxifen may regulate the number and geometry of dendritic spines in CA1 pyramidal neurons of the rat hippocampus.
Young adult male rats were injected with raloxifene (1 mg/kg), tamoxifen (1 mg/kg), or vehicle and killed 24 h after the injection.
Animals treated with raloxifene or tamoxifen showed an increased numerical density of dendritic spines in CA1 pyramidal neurons compared to animals treated with vehicle.
Raloxifene and tamoxifen had also specific effects in the morphology of spines.
These findings suggest that raloxifene and tamoxifen may influence the processing of information by hippocampal pyramidal neurons by affecting the number and shape of dendritic spines.
American Psychological Association (APA)
González-Burgos, Ignacio& Rivera-Cervantes, Martha C.& Velázquez-Zamora, Dulce A.& Feria-Velasco, Alfredo& Garcia-Segura, Luis Miguel. 2011. Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats. Neural Plasticity،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1002389
Modern Language Association (MLA)
González-Burgos, Ignacio…[et al.]. Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats. Neural Plasticity No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1002389
American Medical Association (AMA)
González-Burgos, Ignacio& Rivera-Cervantes, Martha C.& Velázquez-Zamora, Dulce A.& Feria-Velasco, Alfredo& Garcia-Segura, Luis Miguel. Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats. Neural Plasticity. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1002389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002389