SCRAPPER Regulates the Thresholds of Long-Term PotentiationDepression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
Joint Authors
Takagi, Hiroshi
Setou, Mitsutoshi
Ito, Seiji
Yao, Ikuko
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1.
Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin ligase SCRAPPER-deficient hippocampal slices.
Compared to wild-type mice, Scrapper-knockout mice exhibited LTDs with smaller magnitudes after induction with low-frequency stimulation and LTPs with larger magnitudes after induction with tetanus stimulation.
These findings suggest that SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity.
American Psychological Association (APA)
Takagi, Hiroshi& Setou, Mitsutoshi& Ito, Seiji& Yao, Ikuko. 2012. SCRAPPER Regulates the Thresholds of Long-Term PotentiationDepression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses. Neural Plasticity،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002404
Modern Language Association (MLA)
Takagi, Hiroshi…[et al.]. SCRAPPER Regulates the Thresholds of Long-Term PotentiationDepression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses. Neural Plasticity No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1002404
American Medical Association (AMA)
Takagi, Hiroshi& Setou, Mitsutoshi& Ito, Seiji& Yao, Ikuko. SCRAPPER Regulates the Thresholds of Long-Term PotentiationDepression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002404