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Linking Epigenetics to Human Disease and Rett Syndrome: The Emerging Novel and Challenging Concepts in MeCP2 Research
Joint Authors
Zachariah, Robby Mathew
Rastegar, Mojgan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Epigenetics refer to inheritable changes beyond DNA sequence that control cell identity and morphology.
Epigenetics play key roles in development and cell fate commitments and highly impact the etiology of many human diseases.
A well-known link between epigenetics and human disease is the X-linked MECP2 gene, mutations in which lead to the neurological disorder, Rett Syndrome.
Despite the fact that MeCP2 was discovered about 20 years ago, our current knowledge about its molecular function is not comprehensive.
While MeCP2 was originally found to bind methylated DNA and interact with repressor complexes to inhibit and silence its genomic targets, recent studies have challenged this idea.
Indeed, depending on its interacting protein partners and target genes, MeCP2 can act either as an activator or as a repressor.
Furthermore, it is becoming evident that although Rett Syndrome is a progressive and postnatal neurological disorder, the consequences of MeCP2 deficiencies initiate much earlier and before birth.
To comprehend the novel and challenging concepts in MeCP2 research and to design effective therapeutic strategies for Rett Syndrome, a targeted collaborative effort from scientists in multiple research areas to clinicians is required.
American Psychological Association (APA)
Zachariah, Robby Mathew& Rastegar, Mojgan. 2012. Linking Epigenetics to Human Disease and Rett Syndrome: The Emerging Novel and Challenging Concepts in MeCP2 Research. Neural Plasticity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1002412
Modern Language Association (MLA)
Zachariah, Robby Mathew& Rastegar, Mojgan. Linking Epigenetics to Human Disease and Rett Syndrome: The Emerging Novel and Challenging Concepts in MeCP2 Research. Neural Plasticity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1002412
American Medical Association (AMA)
Zachariah, Robby Mathew& Rastegar, Mojgan. Linking Epigenetics to Human Disease and Rett Syndrome: The Emerging Novel and Challenging Concepts in MeCP2 Research. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1002412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002412