Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice
Joint Authors
Krahe, Thomas E.
Seabrook, Tania A.
Chen, Ching-Kang J.
Fox, Michael A.
Guido, William
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The cAMP-response element-binding protein (CREB) plays an important role in visual cortical plasticity that follows the disruption of sensory activity, as induced by dark rearing (DR).
Recent findings indicate that the dorsal lateral geniculate nucleus (dLGN) of thalamus is also sensitive to altered sensory activity.
DR disrupts retinogeniculate synaptic strength and pruning in mice, but only when DR starts one week after eye opening (delayed DR, DDR) and not after chronic DR (CDR) from birth.
While DR upregulates CREB in visual cortex, whether it also modulates this pathway in dLGN remains unknown.
Here we investigate the role of CREB in the dLGN of mice that were CDR or DDR using western blot and immunofluorescence.
Similar to findings in visual cortex, CREB is upregulated in dLGN after CDR and DDR.
These findings are consistent with the proposal that DR up-regulates the CREB pathway in response to decreased visual drive.
American Psychological Association (APA)
Krahe, Thomas E.& Seabrook, Tania A.& Chen, Ching-Kang J.& Fox, Michael A.& Guido, William. 2012. Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice. Neural Plasticity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002414
Modern Language Association (MLA)
Krahe, Thomas E.…[et al.]. Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice. Neural Plasticity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1002414
American Medical Association (AMA)
Krahe, Thomas E.& Seabrook, Tania A.& Chen, Ching-Kang J.& Fox, Michael A.& Guido, William. Modulation of CREB in the Dorsal Lateral Geniculate Nucleus of Dark-Reared Mice. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002414