Cortical GABAergic Interneurons in Cross-Modal Plasticity following Early Blindness
Joint Authors
Desgent, Sébastien
Ptito, Maurice
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-22
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Early loss of a given sensory input in mammals causes anatomical and functional modifications in the brain via a process called cross-modal plasticity.
In the past four decades, several animal models have illuminated our understanding of the biological substrates involved in cross-modal plasticity.
Progressively, studies are now starting to emphasise on cell-specific mechanisms that may be responsible for this intermodal sensory plasticity.
Inhibitory interneurons expressing γ-aminobutyric acid (GABA) play an important role in maintaining the appropriate dynamic range of cortical excitation, in critical periods of developmental plasticity, in receptive field refinement, and in treatment of sensory information reaching the cerebral cortex.
The diverse interneuron population is very sensitive to sensory experience during development.
GABAergic neurons are therefore well suited to act as a gate for mediating cross-modal plasticity.
This paper attempts to highlight the links between early sensory deprivation, cortical GABAergic interneuron alterations, and cross-modal plasticity, discuss its implications, and further provide insights for future research in the field.
American Psychological Association (APA)
Desgent, Sébastien& Ptito, Maurice. 2012. Cortical GABAergic Interneurons in Cross-Modal Plasticity following Early Blindness. Neural Plasticity،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-1002438
Modern Language Association (MLA)
Desgent, Sébastien& Ptito, Maurice. Cortical GABAergic Interneurons in Cross-Modal Plasticity following Early Blindness. Neural Plasticity No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-1002438
American Medical Association (AMA)
Desgent, Sébastien& Ptito, Maurice. Cortical GABAergic Interneurons in Cross-Modal Plasticity following Early Blindness. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-1002438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002438