Synaptic Structure and Function in the Mouse Somatosensory Cortexduring Chronic Pain: In Vivo Two-Photon Imaging
Joint Authors
Kim, Sun Kwang
Eto, Kei
Nabekura, Junichi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Recent advances in two-photon microscopy and fluorescence labeling techniques have enabled us to directly see the structural and functional changes in neurons and glia, and even at synapses, in the brain of living animals.
Long-term in vivo two-photon imaging studies have shown that some postsynaptic dendritic spines in the adult cortex are rapidly eliminated or newly generated, in response to altered sensory input or synaptic activity, resulting in experience/activity-dependent rewiring of neuronal circuits.
In vivo Ca2+ imaging studies have revealed the distinct, input-specific response patterns of excitatory neurons in the brain.
These updated in vivo approaches are just beginning to be used for the study of pathophysiological mechanisms of chronic diseases.
In this paper, we introduce recent in vivo two-photon imaging studies demonstrating how plastic changes in synaptic structure and function of the mouse somatosensory cortex, following peripheral injury, contribute to chronic pain conditions, like neuropathic and inflammatory pain.
American Psychological Association (APA)
Kim, Sun Kwang& Eto, Kei& Nabekura, Junichi. 2012. Synaptic Structure and Function in the Mouse Somatosensory Cortexduring Chronic Pain: In Vivo Two-Photon Imaging. Neural Plasticity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002443
Modern Language Association (MLA)
Kim, Sun Kwang…[et al.]. Synaptic Structure and Function in the Mouse Somatosensory Cortexduring Chronic Pain: In Vivo Two-Photon Imaging. Neural Plasticity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1002443
American Medical Association (AMA)
Kim, Sun Kwang& Eto, Kei& Nabekura, Junichi. Synaptic Structure and Function in the Mouse Somatosensory Cortexduring Chronic Pain: In Vivo Two-Photon Imaging. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002443
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002443