Synaptic Functions of Invertebrate Varicosities: What Molecular Mechanisms Lie Beneath
Joint Authors
Giachello, Carlo Natale Giuseppe
Montarolo, Pier Giorgio
Ghirardi, Mirella
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
In mammalian brain, the cellular and molecular events occurring in both synapse formation and plasticity are difficult to study due to the large number of factors involved in these processes and because the contribution of each component is not well defined.
Invertebrates, such as Drosophila, Aplysia, Helix, Lymnaea, and Helisoma, have proven to be useful models for studying synaptic assembly and elementary forms of learning.
Simple nervous system, cellular accessibility, and genetic simplicity are some examples of the invertebrate advantages that allowed to improve our knowledge about evolutionary neuronal conserved mechanisms.
In this paper, we present an overview of progresses that elucidates cellular and molecular mechanisms underlying synaptogenesis and synapse plasticity in invertebrate varicosities and their validation in vertebrates.
In particular, the role of invertebrate synapsin in the formation of presynaptic terminals and the cell-to-cell interactions that induce specific structural and functional changes in their respective targets will be analyzed.
American Psychological Association (APA)
Giachello, Carlo Natale Giuseppe& Montarolo, Pier Giorgio& Ghirardi, Mirella. 2012. Synaptic Functions of Invertebrate Varicosities: What Molecular Mechanisms Lie Beneath. Neural Plasticity،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1002444
Modern Language Association (MLA)
Giachello, Carlo Natale Giuseppe…[et al.]. Synaptic Functions of Invertebrate Varicosities: What Molecular Mechanisms Lie Beneath. Neural Plasticity No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-1002444
American Medical Association (AMA)
Giachello, Carlo Natale Giuseppe& Montarolo, Pier Giorgio& Ghirardi, Mirella. Synaptic Functions of Invertebrate Varicosities: What Molecular Mechanisms Lie Beneath. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1002444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002444