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Lessons Learned from the Transgenic Huntington's Disease Rats
Joint Authors
Vlamings, Rinske
Zeef, Dagmar H.
Janssen, Marcus L. F.
Oosterloo, Mayke
Schaper, Frederic
Jahanshahi, Ali
Temel, Yasin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Huntington's disease (HD) is a fatal inherited disorder leading to selective neurodegeneration and neuropsychiatric symptoms.
Currently, there is no treatment to slow down or to stop the disease.
There is also no therapy to effectively reduce the symptoms.
In the investigation of novel therapies, different animal models of Huntington's disease, varying from insects to nonhuman primates, have been created and used.
Few years ago, the first transgenic rat model of HD, carrying a truncated huntingtin cDNA fragment with 51 CAG repeats under control of the native rat huntingtin promoter, was introduced.
We have been using this animal model in our research and review here our experience with the behavioural, neurophysiological, and histopathological phenotype of the transgenic Huntington's disease rats with relevant literature.
American Psychological Association (APA)
Vlamings, Rinske& Zeef, Dagmar H.& Janssen, Marcus L. F.& Oosterloo, Mayke& Schaper, Frederic& Jahanshahi, Ali…[et al.]. 2012. Lessons Learned from the Transgenic Huntington's Disease Rats. Neural Plasticity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002445
Modern Language Association (MLA)
Vlamings, Rinske…[et al.]. Lessons Learned from the Transgenic Huntington's Disease Rats. Neural Plasticity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1002445
American Medical Association (AMA)
Vlamings, Rinske& Zeef, Dagmar H.& Janssen, Marcus L. F.& Oosterloo, Mayke& Schaper, Frederic& Jahanshahi, Ali…[et al.]. Lessons Learned from the Transgenic Huntington's Disease Rats. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002445