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Wherefore Art Thou, Homeo(stasis)? Functional Diversity in Homeostatic Synaptic Plasticity
Joint Authors
Queenan, Bridget N.
Lee, Kea Joo
Pak, Daniel T. S.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Homeostatic plasticity has emerged as a fundamental regulatory principle that strives to maintain neuronal activity within optimal ranges by altering diverse aspects of neuronal function.
Adaptation to network activity is often viewed as an essential negative feedback restraint that prevents runaway excitation or inhibition.
However, the precise importance of these homeostatic functions is often theoretical rather than empirically derived.
Moreover, a remarkable multiplicity of homeostatic adaptations has been observed.
To clarify these issues, it may prove useful to ask: why do homeostatic mechanisms exist, what advantages do these adaptive responses confer on a given cell population, and why are there so many seemingly divergent effects? Here, we approach these questions by applying the principles of control theory to homeostatic synaptic plasticity of mammalian neurons and suggest that the varied responses observed may represent distinct functional classes of control mechanisms directed toward disparate physiological goals.
American Psychological Association (APA)
Queenan, Bridget N.& Lee, Kea Joo& Pak, Daniel T. S.. 2012. Wherefore Art Thou, Homeo(stasis)? Functional Diversity in Homeostatic Synaptic Plasticity. Neural Plasticity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1002449
Modern Language Association (MLA)
Queenan, Bridget N.…[et al.]. Wherefore Art Thou, Homeo(stasis)? Functional Diversity in Homeostatic Synaptic Plasticity. Neural Plasticity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1002449
American Medical Association (AMA)
Queenan, Bridget N.& Lee, Kea Joo& Pak, Daniel T. S.. Wherefore Art Thou, Homeo(stasis)? Functional Diversity in Homeostatic Synaptic Plasticity. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1002449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002449