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Kalirin, a Key Player in Synapse Formation, Is Implicated in Human Diseases
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Synapse formation is considered to be crucial for learning and memory.
Understanding the underlying molecular mechanisms of synapse formation is a key to understanding learning and memory.
Kalirin-7, a major isoform of Kalirin in adult rodent brain, is an essential component of mature excitatory synapses.
Kalirin-7 interacts with multiple PDZ-domain-containing proteins including PSD95, spinophilin, and GluR1 through its PDZ-binding motif.
In cultured hippocampal/cortical neurons, overexpression of Kalirin-7 increases spine density and spine size whereas reduction of endogenous Kalirin-7 expression decreases synapse number, and spine density.
In Kalirin-7 knockout mice, spine length, synapse number, and postsynaptic density (PSD) size are decreased in hippocampal CA1 pyramidal neurons; these morphological alterations are accompanied by a deficiency in long-term potentiation (LTP) and a decreased spontaneous excitatory postsynaptic current (sEPSC) frequency.
Human Kalirin-7, also known as Duo or Huntingtin-associated protein-interacting protein (HAPIP), is equivalent to rat Kalirin-7.
Recent studies show that Kalirin is relevant to many human diseases such as Huntington’s Disease, Alzheimer’s Disease, ischemic stroke, schizophrenia, depression, and cocaine addiction.
This paper summarizes our recent understanding of Kalirin function.
American Psychological Association (APA)
Mandela, Prashant& Ma, Xin-Ming. 2012. Kalirin, a Key Player in Synapse Formation, Is Implicated in Human Diseases. Neural Plasticity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1002452
Modern Language Association (MLA)
Mandela, Prashant& Ma, Xin-Ming. Kalirin, a Key Player in Synapse Formation, Is Implicated in Human Diseases. Neural Plasticity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1002452
American Medical Association (AMA)
Mandela, Prashant& Ma, Xin-Ming. Kalirin, a Key Player in Synapse Formation, Is Implicated in Human Diseases. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1002452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002452