AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades
Joint Authors
Man, Heng-Ye
Wang, Guan
Gilbert, James
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Homeostatic synaptic plasticity is a negative-feedback response employed to compensate for functional disturbances in the nervous system.
Typically, synaptic activity is strengthened when neuronal firing is chronically suppressed or weakened when neuronal activity is chronically elevated.
At both the whole cell and entire network levels, activity manipulation leads to a global up- or downscaling of the transmission efficacy of all synapses.
However, the homeostatic response can also be induced locally at subcellular regions or individual synapses.
Homeostatic synaptic scaling is expressed mainly via the regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking and synaptic expression.
Here we review the recently identified functional molecules and signaling pathways that are involved in homeostatic plasticity, especially the homeostatic regulation of AMPAR localization at excitatory synapses.
American Psychological Association (APA)
Wang, Guan& Gilbert, James& Man, Heng-Ye. 2012. AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades. Neural Plasticity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1002458
Modern Language Association (MLA)
Wang, Guan…[et al.]. AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades. Neural Plasticity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1002458
American Medical Association (AMA)
Wang, Guan& Gilbert, James& Man, Heng-Ye. AMPA Receptor Trafficking in Homeostatic Synaptic Plasticity: Functional Molecules and Signaling Cascades. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1002458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002458