Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update
Joint Authors
Keilhoff, Gerburg
Fusar-Poli, Paolo
Becker, Axel
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Schizophrenia is a complex psychiatric disorder.
Although a number of different hypotheses have been developed to explain its aetiopathogenesis, we are far from understanding it.
There is clinical and experimental evidence indicating that neurodevelopmental factors play a major role.
Disturbances in neurodevelopment might result in alterations of neuroanatomy and neurochemistry, leading to the typical symptoms observed in schizophrenia.
The present paper will critically address the neurodevelopmental models underlying schizophrenia by discussing the effects of typical and atypical antipsychotics in animal models.
We will specifically discuss the vitamin D deficiency model, the poly I:C model, the ketamine model, and the postnatal ventral hippocampal lesion model, all of which reflect core neurodevelopmental issues underlying schizophrenia onset.
American Psychological Association (APA)
Keilhoff, Gerburg& Fusar-Poli, Paolo& Becker, Axel. 2012. Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update. Neural Plasticity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1002459
Modern Language Association (MLA)
Keilhoff, Gerburg…[et al.]. Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update. Neural Plasticity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1002459
American Medical Association (AMA)
Keilhoff, Gerburg& Fusar-Poli, Paolo& Becker, Axel. Effects of Antipsychotics on Dentate Gyrus Stem Cell Proliferation and Survival in Animal Models: A Critical Update. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1002459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002459