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The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases
Joint Authors
Kowalski, Jennifer R.
Juo, Peter
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Posttranslational modification of proteins by ubiquitin has emerged as a critical regulator of synapse development and function.
Ubiquitination is a reversible modification mediated by the concerted action of a large number of specific ubiquitin ligases and ubiquitin proteases, called deubiquitinating enzymes (DUBs).
The balance of activity of these enzymes determines the localization, function, and stability of target proteins.
While some DUBs counter the action of specific ubiquitin ligases by removing ubiquitin and editing ubiquitin chains, other DUBs function more generally to maintain the cellular pool of free ubiquitin monomers.
The importance of DUB function at the synapse is underscored by the association of specific mutations in DUB genes with several neurological disorders.
Over the last decade, although much research has led to the identification and characterization of many ubiquitin ligases at the synapse, our knowledge of the relevant DUBs that act at the synapse has lagged.
This review is focused on highlighting our current understanding of DUBs that regulate synaptic function and the diseases that result from dysfunction of these DUBs.
American Psychological Association (APA)
Kowalski, Jennifer R.& Juo, Peter. 2012. The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases. Neural Plasticity،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1002465
Modern Language Association (MLA)
Kowalski, Jennifer R.& Juo, Peter. The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases. Neural Plasticity No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1002465
American Medical Association (AMA)
Kowalski, Jennifer R.& Juo, Peter. The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1002465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002465