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Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-13
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The hippocampus has the extraordinary capacity to process and store information.
Consequently, there is an intense interest in the mechanisms that underline learning and memory.
Synaptic plasticity has been hypothesized to be the neuronal substrate for learning.
Ca2+ and Ca2+-activated kinases control cellular processes of most forms of hippocampal synapse plasticity.
In this paper, I aim to integrate our current understanding of Ca2+-mediated synaptic plasticity and metaplasticity in motivational and reward-related learning in the hippocampus.
I will introduce two representative neuromodulators that are widely studied in reward-related learning (e.g., ghrelin and endocannabinoids) and show how they might contribute to hippocampal neuron activities and Ca2+-mediated signaling processes in synaptic plasticity.
Additionally, I will discuss functional significance of these two systems and their signaling pathways for its relevance to maladaptive reward learning leading to addiction.
American Psychological Association (APA)
Isokawa, Masako. 2012. Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus. Neural Plasticity،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-1002473
Modern Language Association (MLA)
Isokawa, Masako. Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus. Neural Plasticity No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-1002473
American Medical Association (AMA)
Isokawa, Masako. Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus. Neural Plasticity. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-1002473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002473