Reproductive Late Effects in Female Survivors of Childhood Cancer
Joint Authors
Gnaneswaran, Shivany
Deans, Rebecca
Cohn, Richard J.
Source
Obstetrics and Gynecology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Childhood cancer treatments can cause female reproductive late effects.
Radiation to the hypothalamic-pituitary-ovarian axis is associated with altered menarche, miscarriage, and implantation failure.
Patients who receive chemotherapy and/or ovarian radiation are at risk of premature ovarian failure; the risk increases with increasing radiation dose, alkylating agent score, combination therapy, and older age at treatment.
Ovarian reserve may be assessed using antimullerian hormone assay and ultrasound measurements of ovarian volume and antral follicle count; however, their efficacy is poorly established in this cohort.
Fertility preservation options including cryopreservation, oophoropexy, and gonadotropin-releasing hormone analogues may be initiated prior to treatment, although most are still considered experimental.
Uterine radiation has been linked to pregnancy complications including miscarriage, premature delivery, stillbirth, low-birth-weight and small-for-gestational-age infants.
This paper summarises the literature on female reproductive late effects.
The information should facilitate counseling and management of female survivors throughout their reproductive lives.
American Psychological Association (APA)
Gnaneswaran, Shivany& Deans, Rebecca& Cohn, Richard J.. 2012. Reproductive Late Effects in Female Survivors of Childhood Cancer. Obstetrics and Gynecology International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002654
Modern Language Association (MLA)
Gnaneswaran, Shivany…[et al.]. Reproductive Late Effects in Female Survivors of Childhood Cancer. Obstetrics and Gynecology International No. 2012 (Dec. 2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1002654
American Medical Association (AMA)
Gnaneswaran, Shivany& Deans, Rebecca& Cohn, Richard J.. Reproductive Late Effects in Female Survivors of Childhood Cancer. Obstetrics and Gynecology International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002654