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Selective Serotonin Reuptake Inhibitors in Human Pregnancy: To Treat or Not to Treat?
Joint Authors
Source
Obstetrics and Gynecology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Selective serotonin reuptake inhibitors (SSRIs) are increasingly prescribed during pregnancy.
The purpose of the present paper is to summarize and evaluate the current evidence for the risk/benefit analysis of SSRI use in human pregnancy.
The literature has been inconsistent.
Although most studies have not shown an increase in the overall risk of major malformations, several studies have suggested that SSRIs may be associated with a small increased risk for cardiovascular malformations.
Others have noted associations between SSRIs and specific types of rare major malformations.
In some studies, there appears to be a small increased risk for miscarriages, which may be associated with the underlying maternal condition.
Neonatal effects have been described in up to 30% of neonates exposed to SSRIs late in pregnancy.
Persistent pulmonary hypertension of the newborn has also been described with an absolute risk of <1%.
The risk associated with treatment discontinuation, for example, higher frequency of relapse and increased risk of preterm delivery, should also be considered.
The overall benefit of treatment seems to outweigh the potential risks.
American Psychological Association (APA)
Diav-Citrin, Orna& Ornoy, Asher. 2011. Selective Serotonin Reuptake Inhibitors in Human Pregnancy: To Treat or Not to Treat?. Obstetrics and Gynecology International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1002676
Modern Language Association (MLA)
Diav-Citrin, Orna& Ornoy, Asher. Selective Serotonin Reuptake Inhibitors in Human Pregnancy: To Treat or Not to Treat?. Obstetrics and Gynecology International No. 2012 (Dec. 2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1002676
American Medical Association (AMA)
Diav-Citrin, Orna& Ornoy, Asher. Selective Serotonin Reuptake Inhibitors in Human Pregnancy: To Treat or Not to Treat?. Obstetrics and Gynecology International. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1002676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002676