Genetic Rat Models of Parkinson's Disease
Joint Authors
Welchko, Ryan M.
Dunbar, Gary L.
Lévêque, Xavier T.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Parkinson’s disease (PD) is a neurodegenerative disease characterized by a specific loss of dopaminergic neurons.
Although the vast majority of PD cases are idiopathic in nature, there is a subset that contains genetic links.
Of the genes that have been linked to PD, α-synuclein and leucine-rich repeat kinase 2 have been used to develop transgenic rat models of the disease.
In this paper we focused on the various transgenic rat models of PD in terms of their ability to mimic key symptoms of PD in a progressive manner.
In general, we found that most of these models provided useful tools for the early stages of PD, but the development of new transgenic rats that present significant neuropathologic and motoric deficits in a progressive manner that more accurately mimics PD is needed.
American Psychological Association (APA)
Welchko, Ryan M.& Lévêque, Xavier T.& Dunbar, Gary L.. 2012. Genetic Rat Models of Parkinson's Disease. Parkinson’s Disease،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1002712
Modern Language Association (MLA)
Welchko, Ryan M.…[et al.]. Genetic Rat Models of Parkinson's Disease. Parkinson’s Disease No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1002712
American Medical Association (AMA)
Welchko, Ryan M.& Lévêque, Xavier T.& Dunbar, Gary L.. Genetic Rat Models of Parkinson's Disease. Parkinson’s Disease. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1002712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002712