Mitochondrial Dynamics and Mitophagy in the 6-Hydroxydopamine Preclinical Model of Parkinson's Disease
Joint Authors
Zamora, Maria J.
Jordán Bueso, Joaquín
Atienzar-Aroca, Sandra
Galindo, Maria F.
Solesio, Maria E.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We discuss the participation of mitochondrial dynamics and autophagy in the 6-hydroxidopamine-induced Parkinson’s disease model.
The regulation of dynamic mitochondrial processes such as fusion, fission, and mitophagy has been shown to be an important mechanism controlling cellular fate.
An imbalance in mitochondrial dynamics may contribute to both familial and sporadic neurodegenerative diseases including Parkinson’s disease.
With special attention we address the role of second messengers as the role of reactive oxygen species and the mitochondria as the headquarters of cell death.
The role of molecular signaling pathways, for instance, the participation of Dynamin-related protein 1(Drp1), will also be addressed.
Furthermore evidence demonstrates the therapeutic potential of small-molecule inhibitors of mitochondrial division in Parkinson’s disease.
For instance, pharmacological inhibition of Drp1, through treatment with the mitochondrial division inhibitor-1, results in the abrogation of mitochondrial fission and in a decrease of the number of autophagic cells.
Deciphering the signaling cascades that underlie mitophagy triggered by 6-OHDA, as well as the mechanisms that determine the selectivity of this response, will help to better understand this process and may have impact on human treatment strategies of Parkinson’s disease.
American Psychological Association (APA)
Galindo, Maria F.& Solesio, Maria E.& Atienzar-Aroca, Sandra& Zamora, Maria J.& Jordán Bueso, Joaquín. 2012. Mitochondrial Dynamics and Mitophagy in the 6-Hydroxydopamine Preclinical Model of Parkinson's Disease. Parkinson’s Disease،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002723
Modern Language Association (MLA)
Galindo, Maria F.…[et al.]. Mitochondrial Dynamics and Mitophagy in the 6-Hydroxydopamine Preclinical Model of Parkinson's Disease. Parkinson’s Disease No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1002723
American Medical Association (AMA)
Galindo, Maria F.& Solesio, Maria E.& Atienzar-Aroca, Sandra& Zamora, Maria J.& Jordán Bueso, Joaquín. Mitochondrial Dynamics and Mitophagy in the 6-Hydroxydopamine Preclinical Model of Parkinson's Disease. Parkinson’s Disease. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002723