Dyskinesias and Treatment with Pramipexole in Patients with Parkinson's Disease
Joint Authors
Piedad, John C. P.
Cavanna, Andrea Eugenio
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Dopamine agonists such as pramipexole (PPX) have first been proposed as adjunctive treatment to levodopa (L-DOPA) for patients with Parkinson’s disease (PD) and then as a monotherapy alternative to alleviate dyskinesia.
Treatment with PPX has overall been associated with improvement in parkinsonian symptoms.
Although the majority of placebo-controlled studies demonstrated that dyskinesia was more prevalent in the PPX compared to the placebo groups, some studies did not detect any dyskinesia as a side effect of this medication.
PPX was consistently associated with lower risk for developing dyskinesia compared to L-DOPA.
Moreover, the presence of these symptoms in the placebo groups suggests involvement of non-PPX-related factors for developing dyskinesia.
It is suggested that future research should aim at ascertaining whether cotherapy with L-DOPA, PPX dosage, and other patient characteristics are contributory factors for the development of PPX-related dyskinesia in patients with PD.
American Psychological Association (APA)
Piedad, John C. P.& Cavanna, Andrea Eugenio. 2012. Dyskinesias and Treatment with Pramipexole in Patients with Parkinson's Disease. Parkinson’s Disease،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002799
Modern Language Association (MLA)
Piedad, John C. P.& Cavanna, Andrea Eugenio. Dyskinesias and Treatment with Pramipexole in Patients with Parkinson's Disease. Parkinson’s Disease No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1002799
American Medical Association (AMA)
Piedad, John C. P.& Cavanna, Andrea Eugenio. Dyskinesias and Treatment with Pramipexole in Patients with Parkinson's Disease. Parkinson’s Disease. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002799