A2A Receptor Antagonism and Dyskinesia in Parkinson’s Disease
Joint Authors
Hauser, Robert A.
Blandini, Fabio
Morelli, Micaela
Simola, Nicola
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Dyskinesia, a major complication of treatment of Parkinson’s disease (PD), involves two phases: induction, which is responsible for dyskinesia onset, and expression, which underlies its clinical manifestation.
The unique cellular and regional distribution of adenosine A2A receptors in basal ganglia areas that are richly innervated by dopamine, and their antagonistic role towards dopamine receptor stimulation, have positioned A2A receptor antagonists as an attractive nondopaminergic target to improve the motor deficits that characterize PD.
In this paper, we describe the biochemical characteristics of A2A receptors and the effects of adenosine A2A antagonists in rodent and primate models of PD on L-DOPA-induced dyskinesia, together with relevant biomarker studies.
We also review clinical trials of A2A antagonists as adjuncts to L-DOPA in PD patients with motor fluctuations.
These studies have generally demonstrated that the addition of an A2A antagonist to a stable L-DOPA regimen reduces OFF time and mildly increases dyskinesia.
However, limited clinical data suggest that the addition of an A2A antagonist along with a reduction of L-DOPA might maintain anti-Parkinsonian benefit and reduce dyskinesia.
Whether A2A antagonists might reduce the development of dyskinesia has not yet been tested clinically.
American Psychological Association (APA)
Morelli, Micaela& Blandini, Fabio& Simola, Nicola& Hauser, Robert A.. 2012. A2A Receptor Antagonism and Dyskinesia in Parkinson’s Disease. Parkinson’s Disease،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002800
Modern Language Association (MLA)
Morelli, Micaela…[et al.]. A2A Receptor Antagonism and Dyskinesia in Parkinson’s Disease. Parkinson’s Disease No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1002800
American Medical Association (AMA)
Morelli, Micaela& Blandini, Fabio& Simola, Nicola& Hauser, Robert A.. A2A Receptor Antagonism and Dyskinesia in Parkinson’s Disease. Parkinson’s Disease. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002800