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Adenosine A2A Receptor Antagonists Do Not Disrupt Rodent Prepulse Inhibition: An Improved Side Effect Profile in the Treatment of Parkinson's Disease
Joint Authors
Bleickardt, Carina J.
Merkel, Carrie E.
LaShomb, Abigail L.
Hodgson, Robert A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Parkinson's disease (PD) is characterized by loss of dopaminergic neurons in the substantia nigra.
Current treatments for PD focus on dopaminergic therapies, including L-dopa and dopamine receptor agonists.
However, these treatments induce neuropsychiatric side effects.
Psychosis, characterized by delusions and hallucinations, is one of the most serious such side effects.
Adenosine A2A receptor antagonism is a nondopaminergic treatment for PD with clinical and preclinical efficacy.
The present studies assessed A2A antagonists SCH 412348 and istradefylline in rodent prepulse inhibition (PPI), a model of psychosis.
Dopamine receptor agonists pramipexole (0.3–3 mg/kg), pergolide (0.3–3 mg/kg), and apomorphine (0.3–3 mg/kg) significantly disrupted PPI; ropinirole (1–30 mg/kg) had no effect; L-dopa (100–300 mg/kg) disrupted rat but not mouse PPI.
SCH 412348 (0.3–3 mg/kg) did not disrupt rodent PPI; istradefylline (0.1–1 mg/kg) marginally disrupted mouse but not rat PPI.
These results suggest that A2A antagonists, unlike dopamine agonists, have an improved neuropsychiatric side effect profile.
American Psychological Association (APA)
Bleickardt, Carina J.& LaShomb, Abigail L.& Merkel, Carrie E.& Hodgson, Robert A.. 2011. Adenosine A2A Receptor Antagonists Do Not Disrupt Rodent Prepulse Inhibition: An Improved Side Effect Profile in the Treatment of Parkinson's Disease. Parkinson’s Disease،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1002808
Modern Language Association (MLA)
Bleickardt, Carina J.…[et al.]. Adenosine A2A Receptor Antagonists Do Not Disrupt Rodent Prepulse Inhibition: An Improved Side Effect Profile in the Treatment of Parkinson's Disease. Parkinson’s Disease No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1002808
American Medical Association (AMA)
Bleickardt, Carina J.& LaShomb, Abigail L.& Merkel, Carrie E.& Hodgson, Robert A.. Adenosine A2A Receptor Antagonists Do Not Disrupt Rodent Prepulse Inhibition: An Improved Side Effect Profile in the Treatment of Parkinson's Disease. Parkinson’s Disease. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1002808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002808