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Proteomic Technologies for the Study of Osteosarcoma
Joint Authors
Montgomery, Corey O.
Tackett, Alan J.
Washam, Charity L.
Suva, Larry J.
Byrum, Stephanie D.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Osteosarcoma is the most common primary bone cancer of children and is established during stages of rapid bone growth.
The disease is a consequence of immature osteoblast differentiation, which gives way to a rapidly synthesized incompletely mineralized and disorganized bone matrix.
The mechanism of osteosarcoma tumorogenesis is poorly understood, and few proteomic studies have been used to interrogate the disease thus far.
Accordingly, these studies have identified proteins that have been known to be associated with other malignancies, rather than being osteosarcoma specific.
In this paper, we focus on the growing list of available state-of-the-art proteomic technologies and their specific application to the discovery of novel osteosarcoma diagnostic and therapeutic targets.
The current signaling markers/pathways associated with primary and metastatic osteosarcoma that have been identified by early-stage proteomic technologies thus far are also described.
American Psychological Association (APA)
Byrum, Stephanie D.& Washam, Charity L.& Montgomery, Corey O.& Tackett, Alan J.& Suva, Larry J.. 2012. Proteomic Technologies for the Study of Osteosarcoma. Complexity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1002870
Modern Language Association (MLA)
Byrum, Stephanie D.…[et al.]. Proteomic Technologies for the Study of Osteosarcoma. Complexity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1002870
American Medical Association (AMA)
Byrum, Stephanie D.& Washam, Charity L.& Montgomery, Corey O.& Tackett, Alan J.& Suva, Larry J.. Proteomic Technologies for the Study of Osteosarcoma. Complexity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1002870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002870