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Bone Sarcomas: From Biology to Targeted Therapies
Joint Authors
Brugieres, Laurence
Geoerger, Birgit
Gaspar, Nathalie
Piperno-Neumann, Sophie
Laurence, Valérie
Redini, Françoise
Di Giannatale, Angela
Marec-Bérard, Perrine
Oberlin, Odile
Enz-Werle, Natacha
Gentet, Jean-Claude
Tirode, Franck
Corradini, Nadège
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-27
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Primary malignant bone tumours, osteosarcomas, and Ewing sarcomas are rare diseases which occur mainly in adolescents and young adults.
With the current therapies, some patients remain very difficult to treat, such as tumour with poor histological response to preoperative CT (or large initial tumour volume for Ewing sarcomas not operated), patients with multiple metastases at or those who relapsed.
In order to develop new therapies against these rare tumours, we need to unveil the key driving factors and molecular abnormalities behind the malignant characteristics and to broaden our understanding of the phenomena sustaining the metastatic phenotype and treatment resistance in these tumours.
In this paper, starting with the biology of these tumours, we will discuss potential therapeutic targets aimed at increasing local tumour control, limiting metastatic spread, and finally improving patient survival.
American Psychological Association (APA)
Gaspar, Nathalie& Di Giannatale, Angela& Geoerger, Birgit& Redini, Françoise& Corradini, Nadège& Enz-Werle, Natacha…[et al.]. 2012. Bone Sarcomas: From Biology to Targeted Therapies. Complexity،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-1002883
Modern Language Association (MLA)
Gaspar, Nathalie…[et al.]. Bone Sarcomas: From Biology to Targeted Therapies. Complexity No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-1002883
American Medical Association (AMA)
Gaspar, Nathalie& Di Giannatale, Angela& Geoerger, Birgit& Redini, Françoise& Corradini, Nadège& Enz-Werle, Natacha…[et al.]. Bone Sarcomas: From Biology to Targeted Therapies. Complexity. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-1002883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002883