Calcitriol Inhibits Hedgehog Signaling and Induces Vitamin D Receptor Signaling and Differentiation in the Patched Mouse Model of Embryonal Rhabdomyosarcoma
Joint Authors
Niemann, Hannah
Schulz-Schaeffer, Walter
Lammering, Bérénice
Heß, Ina
Schraepler, Anke
Henkel, Cornelia
Uhmann, Anja
Rosenberger, Albert
Hahn, Heidi
Dullin, Christian
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children.
Aberrant Hedgehog (Hh) signaling is characteristic of the embryonal subtype (ERMS) and of fusion-negative alveolar RMS.
In the mouse, ERMS-like tumors can be induced by mutations in the Hh receptor Patched1 (Ptch).
As in humans these tumors show increased Hh pathway activity.
Here we demonstrate that the treatment with the active form of vitamin D3, calcitriol, inhibits Hh signaling and proliferation of murine ERMS in vivo and in vitro.
Concomitantly, calcitriol activates vitamin D receptor (Vdr) signaling and induces tumor differentiation.
In addition, calcitriol inhibits ERMS growth in Ptch-mutant mice, which is, however, a rather late response.
Taken together, our results suggest that exogenous supply of calcitriol could be beneficial in the treatment of RMS, especially in those which are associated with aberrant Hh signaling activity.
American Psychological Association (APA)
Uhmann, Anja& Niemann, Hannah& Lammering, Bérénice& Henkel, Cornelia& Heß, Ina& Rosenberger, Albert…[et al.]. 2012. Calcitriol Inhibits Hedgehog Signaling and Induces Vitamin D Receptor Signaling and Differentiation in the Patched Mouse Model of Embryonal Rhabdomyosarcoma. Complexity،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002891
Modern Language Association (MLA)
Uhmann, Anja…[et al.]. Calcitriol Inhibits Hedgehog Signaling and Induces Vitamin D Receptor Signaling and Differentiation in the Patched Mouse Model of Embryonal Rhabdomyosarcoma. Complexity No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1002891
American Medical Association (AMA)
Uhmann, Anja& Niemann, Hannah& Lammering, Bérénice& Henkel, Cornelia& Heß, Ina& Rosenberger, Albert…[et al.]. Calcitriol Inhibits Hedgehog Signaling and Induces Vitamin D Receptor Signaling and Differentiation in the Patched Mouse Model of Embryonal Rhabdomyosarcoma. Complexity. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1002891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002891