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Classification, Molecular Characterization, and the Significance of Pten Alteration in Leiomyosarcoma
Joint Authors
Layfield, Lester J.
Randall, R. Lor
Grossmann, Allie H.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Leiomyosarcoma is a malignant smooth muscle neoplasm with a complicated histopathologic classification scheme and marked differences in clinical behavior depending on the anatomic site of origin.
Overlapping morphologic features of benign and borderline malignant smooth muscle neoplasms further complicate the diagnostic process.
Likewise, deciphering the complex and heterogeneous patterns of genetic changes which occur in this cancer has been challenging.
Preliminary studies suggest that reproducible molecular classification may be possible in the near future and new prognostic markers are emerging.
Robust recapitulation of leiomyosarcoma in mice with conditional deletion of Pten in smooth muscle and the simultaneous discovery of a novel role for Pten in genomic stability provide a fresh perspective on the mechanism of leiomyosarcomagenesis and promise for therapeutic intervention.
American Psychological Association (APA)
Grossmann, Allie H.& Layfield, Lester J.& Randall, R. Lor. 2012. Classification, Molecular Characterization, and the Significance of Pten Alteration in Leiomyosarcoma. Complexity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002894
Modern Language Association (MLA)
Grossmann, Allie H.…[et al.]. Classification, Molecular Characterization, and the Significance of Pten Alteration in Leiomyosarcoma. Complexity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1002894
American Medical Association (AMA)
Grossmann, Allie H.& Layfield, Lester J.& Randall, R. Lor. Classification, Molecular Characterization, and the Significance of Pten Alteration in Leiomyosarcoma. Complexity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002894