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MAPKERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions
Joint Authors
Staples, J. Robert
Lee, Francis Youngin
Kim, Yuhree
Hahn, Cody
Chandhanayingyong, Chandhanarat
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The introduction of cytotoxic chemotherapeutic drugs in the 1970’s improved the survival rate of patients with bone sarcomas and allowed limb salvage surgeries.
However, since the turn of the century, survival data has plateaued for a subset of metastatic, nonresponding osteo, and/or Ewing sarcomas.
In addition, most high-grade chondrosarcoma does not respond to current chemotherapy.
With an increased understanding of molecular pathways governing oncogenesis, modern targeted therapy regimens may enhance the efficacy of current therapeutic modalities.
Mitogen-Activated Protein Kinases (MAPK)/Extracellular-Signal-Regulated Kinases (ERK) are key regulators of oncogenic phenotypes such as proliferation, invasion, angiogenesis, and inflammatory responses; which are the hallmarks of cancer.
Consequently, MAPK/ERK inhibitors have emerged as promising therapeutic targets for certain types of cancers, but there have been sparse reports in bone sarcomas.
Scattered papers suggest that MAPK targeting inhibits proliferation, local invasiveness, metastasis, and drug resistance in bone sarcomas.
A recent clinical trial showed some clinical benefits in patients with unresectable or metastatic osteosarcomas following MAPK/ERK targeting therapy.
Despite in vitro proof of therapeutic concept, there are no sufficient in vivo or clinical data available for Ewing sarcomas or chondrosarcomas.
Further experimental and clinical trials are awaited in order to bring MAPK targeting into a clinical arena.
American Psychological Association (APA)
Chandhanayingyong, Chandhanarat& Kim, Yuhree& Staples, J. Robert& Hahn, Cody& Lee, Francis Youngin. 2012. MAPKERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions. Complexity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002896
Modern Language Association (MLA)
Chandhanayingyong, Chandhanarat…[et al.]. MAPKERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions. Complexity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1002896
American Medical Association (AMA)
Chandhanayingyong, Chandhanarat& Kim, Yuhree& Staples, J. Robert& Hahn, Cody& Lee, Francis Youngin. MAPKERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions. Complexity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1002896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002896