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The Genetics of Osteosarcoma
Joint Authors
Zielenska, Maria
Squire, Jeremy A.
Martin, Jeff W.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in children and adolescents relative to other age groups.
The etiology of this often aggressive cancer is currently unknown, because complicated structural and numeric genomic rearrangements in cancer cells preclude understanding of tumour development.
In addition, few consistent genetic changes that may indicate effective molecular therapeutic targets have been reported.
However, high-resolution techniques continue to improve knowledge of distinct areas of the genome that are more commonly associated with osteosarcomas.
Copy number gains at chromosomes 1p, 1q, 6p, 8q, and 17p as well as copy number losses at chromosomes 3q, 6q, 9, 10, 13, 17p, and 18q have been detected by numerous groups, but definitive oncogenes or tumour suppressor genes remain elusive with respect to many loci.
In this paper, we examine studies of the genetics of osteosarcoma to comprehensively describe the heterogeneity and complexity of this cancer.
American Psychological Association (APA)
Martin, Jeff W.& Squire, Jeremy A.& Zielenska, Maria. 2012. The Genetics of Osteosarcoma. Complexity،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1002913
Modern Language Association (MLA)
Martin, Jeff W.…[et al.]. The Genetics of Osteosarcoma. Complexity No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1002913
American Medical Association (AMA)
Martin, Jeff W.& Squire, Jeremy A.& Zielenska, Maria. The Genetics of Osteosarcoma. Complexity. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1002913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1002913